RiteMED Bisoprolol

Bisoprolol fumarate

Management of HTN, angina & heart failure.

Individualized dosage. Essential HTN 5 mg once daily. Diastolic BP up to 105 mmHg 2.5 mg once daily. May be increased up to 10 mg once daily if required. Max: 20 mg once daily. CHD (angina pectoris) 5 mg once daily. May be increased to 10 mg once daily. Max: 20 mg once daily.

May be taken with or without food.

Hypersensitivity. Acute heart failure, cardiogenic shock, 2nd- or 3rd-degree AV block (w/o pacemaker), sick sinus syndrome, SA block; symptomatic bradycardia or hypotension; severe bronchial asthma or COPD, severe forms of peripheral arterial occlusive disease or Raynaud's syndrome, untreated pheochromocytoma & metabolic acidosis.

Patients w/ ischemic heart disease, HTN, angina pectoris & accompanying heart failure; DM, 1st-degree AV block, Prinzmetal's angina, peripheral arterial occlusive disease, ongoing desensitization therapy & those on strict fasting; existing or history of psoriasis, pheochromocytoma & those undergoing general anesth. Avoid abrupt w/drawal. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn.

Bradycardia; worsening of preexisting heart failure, dizziness, headache; GI complaints eg, nausea, vomiting, diarrhea, constipation; feeling coldness or numbness in extremities, hypotension & asthenia.

Potentiated AV conduction time & increased -ve inotropic effect w/ class I & III antiarrhythmic drugs (eg, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone, amiodarone). Increased AV conduction time w/ parasympathomimetics & digitalis glycosides. Increased risk of hypotension w/ Ca channel blockers, anesth, MAOIs & other drugs w/ BP-lowering potential (eg, TCAs, barbiturates, phenothiazide). Potential systemic effect w/ topical β-blockers. Increased blood sugar-lowering effect w/ insulin & oral antidiabetic drugs. Reduced hypotensive effect w/ NSAIDs. May reduce effect w/ β-sympathomimetics (eg, isoprenaline, dobutamine). Increased risk of bradycardia w/ mefloquine. Risk of hypertensive crisis w/ MAOIs. Reduced t_½ w/ rifampicin. Exacerbation of peripheral circulatory disturbance w/ ergotamine derivatives.

Beta-Blockers

C07AB07 - bisoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

Rx